Jump to content

LPP (gene)

From Wikipedia, the free encyclopedia
LPP
Identifiers
AliasesLPP, LIM domain containing preferred translocation partner in lipoma
External IDsOMIM: 600700; MGI: 2441849; HomoloGene: 4075; GeneCards: LPP; OMA:LPP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145952
NM_001145954
NM_178665

RefSeq (protein)

NP_001139424
NP_001139426
NP_848780

Location (UCSC)Chr 3: 188.15 – 188.89 MbChr 16: 24.39 – 24.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.[5][6]

Function

[edit]

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145012Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033306Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family". Genomics. 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423.
  6. ^ a b "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma".

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.